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ES-KRED-101~ ES-KRED-281 a set of 181 ketoreductases, 50 mg each 181 items * 50mg / item, or other quantity. Screening Kit (Synkit) ES-KRED-9400. 94 items*1mg / item

KRED 101 99% conversion 99% ee, 99% de Liang, J. and co-workers Org. Proc. Res. Dev. 2010, 14, 193 An evolved ketoreductase has been developed for an industrial scale synthesis (> 200 kg) of a Singulair (montelukast sodium) intermediate. N O OOMe Cl N OOMe Cl OH 233 kg, 97%, > 99.9% ee evolved ketoreductase isopropanol, water KRED-101 KRED-130 Key: In-house Heterologous Expression, commercial from Sigma-Aldrich, commercial from Prozomix®, commercial from Codexis®. Bold text indicates KREDs that utilized KRED Recycle Mix N (GDH/glucose turnover). All others used KRED Recycle Mix P (IPA turnover). Procedure: a) Preparation of stock solutions: Also, intermediate (XV) can be produced by enzymatic reduction of ketone (XI) using KRED-101 in the presence of GDH, NADP, KOH and PEG-400, KRED-X1.1-P1F01 in the presence of glucose and NAD in DMSO/i-PrOH or KRED-X1.1-P1B06, KRED-X1.1-P1F01 or KRED-X1.1-P1H10 in the presence of NADP in DMSO/i-PrOH or i-PrOH (11,12). Biocatalytics KRED 101 has been shown to selectively reduce the (6R,9S) enantiomer leaving behind the desired (6S,9R) enantiomer.

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100-101. Utses att justera. Kent Ballovarre (S). Justeringens plats och tid. Kommunhuset i Älmhult 2016-09-14 Underskrift Kred aubtudien.

HIV. Human immunodeficiency virus. KRED 101. Busto E., Simon R. C., Richter N., Kroutil W., "One-Pot, Two-Module. För ytterligare information hänvisas till KRED 2017:3.

The five natural enzymes (KREDs 20–24 in the table on the next page: KRED-101, KRED-119, KRED-130, KRED-NADH-101 and KRED-NADH-110) work poorly with IPA and therefore use glucose and glucose dehydrogenase (GDH) instead of IPA for cofactor recycling. KREDs 23 (KRED-NADH-101) and 24 (KRED-NADH-110) use NADH as a cofactor instead of NADPH.

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The reaction rate was determined to be linearly proportional to the catalyst loading ( Fig. 2 ), demonstrating that the reaction was not in a mass transfer limited regime at the enzyme concentrations studied.
Bottom loading vacuum furnace

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IntroductionRivastigmine {(S)-3-[1-(dimethylamino)-ethyl]phenyl ethyl-(methyl)carbamate} 1 is an active pharmaceutical ingredient which inhibits acetylcholinesterase enzymes present in the nervous system.

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examples: *. P2-G03: 98% conversion, er = 99:1 (S). P2-D12: 99%, er = 93:7 (R). 75% isolated yield. O. O. OH. KRED 101: 99% er = 99.5:0.5. 23% isolated yield.

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